Dr. Madhavi Hewadikaram

Senior Lecturer



Dr. Madhavi Hewadikaram is a B.Sc. Zoology (special degree) graduate from the Faculty of Applied Sciences, University of Sri Jayewardenepura Sri Lanka. She has got a first-class degree and was awarded the coveted 2011 Gold Medal for the best performing student in Zoology. She obtained her Master’s degree in Biology from the Central Michigan University USA in 2015. She was specialized in Genomics, Bioinformatics and Molecular Biology areas. Currently, PhD in Synthetic Biology and Molecular Biology from the Sri Lanka Institute of Nano Technology. Her research focuses mainly on molecular diagnostic techniques in human diseases and understanding biosynthetic pathways of important medicinal plants that are important in biopharmaceuticals. She aims to produce those essential metabolites via bacterial and yeast cells to increase the yield and cheaper products to the pharmaceutical industry.

She has served as a lecturer at the Faculty of Applied Sciences, University of Sri Jayewardenepura, and as a teaching assistant at the Department of Biology at Central Michigan University, the USA, during her eight years’ experience in academia. In addition, she has worked as a research scientist at the Sri Lanka Institute of Nanotechnology and was a pioneer member to implement molecular diagnostic LAMP KIT for SARS COV-2 Detection for Sri Lankan patients.

Research Interests

  • RNA Sequencing based transcriptome analysis to understand medically important unknown biosynthesis pathways in plants and animals and their end production in heterologous host species.
  • Molecular detection techniques to diagnose upcoming human diseases in Sri Lanka

Journal Publications

  1. Welideniya, Dhanushi T.; Jayathilaka, Adeesha S.; Delpe Acharige, Anjana.; Samanthi, K.A.U.; Wanninayake, Umayangani K.; Shashika, S.; Rajapaksha, Weranga.; Fernando,Chamod C.; Hewadikaram, Madhavi.; Buddhika, Janani.; Gunasekara,Pivini.; Karunaratne,Veranja.; Amaratunga, G A J.; Gunasekera, Dinara S.(2022), Practical and scalable synthesis of beclomethasone dipropionate,Steroids,177, 108948,0039-128X,
  2. Hewadikaram M, Perera K, Dissanayake K, Ramanayake M, Isurika SC, Panch A, Jayarathne A, Pushpakumara P, Malavige N, Jeewandara C, Bathige SDNK, Mubarak AM. Development of Duplex and Multiplex Reverse Transcription Loop Mediated Isothermal Amplification (RT-LAMP) Assays for Clinical Diagnosis of SARS-COV-2 in Sri Lanka. Int J Infect Dis. 2022 Mar;116:S39–40. doi: 10.1016/j.ijid.2021.12.095. Epub 2022 Feb 28. PMCID: PMC8884781.
  3. Hewadikaramge, M.E., Linton, E. (2018) .Intrageneric chloroplast genome comparison in the genus Euglena (Phylum: Euglenophyta) with annotated chloroplast genomes of Euglena hiemalis and Euglena clara. J Appl Phycol 30, 3167–3177

Conference (Full Paper) Publications

  1. Hewadikaram, Madhavi.; De Silva, Kithmee. (2022). Weighted Gene Co-expression Network Analysis to Identify Key Modules and Hub Genes Related to Withanoloides Biosynthesis Pathway in Datura metel. 5th International Conference on Business Innovation, 2651-0103, 478. .
  2. Hewadikaram, Madhavi.; Perera, Hasith. ; Bathige, Sanjaya.; Karunaratne, Veranja., (2022). Identification of genes involved in the biosynthesis of secondary metabolites in D.metel via transcriptomic analysis of leaf and flower tissues, 21st International Conference on Bioinformatics (Incob 2022), November 2022
  3. Hewadikaram, Madhavi, Bathige, Sanjaya.; Karunaratne, Veranja. (2021). In Silico Gene Expression Analysis of P450 87A3 Candidate Gene for Withanolides Production in Datura metal plant, A special symposium celebrating 50th anniversary of the Protein Data Bank, held by The American Society for Biochemistry and Molecular Biology and the World Wide Protein Data Bank USA, 78

Ongoing Research

  1. De novo seqeuncing and transcriptome analysis of D.metel tissues
  2. Metagenomics analysis of hotwater spring microbes